Synthesis of tetrazole hybridized with thiazole, thiophene or thiadiazole derivatives, molecular modelling and antimicrobial activity.

ABSTRACT:

Background

Tetrazole-based derivatives and their electronic structures have displayed interesting antimicrobial activity.

Methods

The tetrazole-based hybrids linked with thiazole, thiophene and thiadiazole ring systems have been synthesized through various chemical reactions. The computational method DFT/B3LYP has been utilized to calculate their electronic properties. The antimicrobial effectiveness was investigated against representative bacterial and fungal strains. Additionally, the synthesized derivatives binding interaction was stimulated by docking program against PDB ID: 4URO as a model of the ATP binding domain of S. aureus DNA Gyrase subunit B.

Results

The structures of the synthesized tetrazole-based derivatives were confirmed by IR, NMR, and Mass sp

SUBMITTER: Abualnaja MM 

PROVIDER: S-EPMC10840348 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature