Disulfide bridge-targeted metabolome mining unravels an antiparkinsonian peptide.

ABSTRACT: Peptides are a particular molecule class with inherent attributes of some small-molecule drugs and macromolecular biologics, thereby inspiring continuous searches for peptides with therapeutic and/or agrochemical potentials. However, the success rate is decreasing, presumably because many interesting but less-abundant peptides are so scarce or labile that they are likely 'overlooked' during the characterization effort. Here, we present the biochemical characterization and druggability improvement of an unprecedented minor fungal RiPP (ribosomally synthesized and post-translationally modified peptide), named acalitide, by taking the relevant advantages of metabolomics approach and disulfide-bridged substructure which is more frequently imprinted in the marketed peptide drug molecules. Acali

SUBMITTER: Tong Z 

PROVIDER: S-EPMC10840396 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature