Prenatal Metal Exposures and Child Social Responsiveness Scale Scores in 2 Prospective Studies.

ABSTRACT:

Background

Prenatal exposure to metals is hypothesized to be associated with child autism. We aim to investigate the joint and individual effects of prenatal exposure to urine metals including lead (Pb), mercury (Hg), manganese (Mn), and selenium (Se) on child Social Responsiveness Scale (SRS) scores.

Methods

We used data from 2 cohorts enriched for likelihood of autism spectrum disorder (ASD): Early Autism Risk Longitudinal Investigation (EARLI) and the Markers of Autism Risk in Babies-Learning Early Signs (MARBLES) studies. Metal concentrations were measured in urine collected during pregnancy. We used Bayesian Kernel Machine Regression and linear regression models to investigate both joint and independent associations of metals with SRS Z-scores in each cohort. We adjuste

SUBMITTER: Yu EX 

PROVIDER: S-EPMC10840406 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature