AT(N) biomarker profiles and Alzheimer's disease symptomology in Down syndrome.

ABSTRACT:

Introduction

Down syndrome (DS) is a genetic cause of early-onset Alzheimer's disease (AD). The National Institute on Aging-Alzheimer's Association AT(N) Research Framework is a staging model for AD biomarkers but has not been assessed in DS.

Method

Data are from the Alzheimer's Biomarker Consortium-Down Syndrome. Positron emission tomography (PET) amyloid beta (Aβ; 15 mCi of [¹¹ C]Pittsburgh compound B) and tau (10 mCi of [¹⁸ F]AV-1451) were used to classify amyloid (A) -/+ and tau (T) +/-. Hippocampal volume classified neurodegeneration (N) -/+. The modified Cued Recall Test assessed episodic memory.

Results

Analyses included 162 adults with DS (aged M = 38.84 years, standard deviation = 8.41). Overall, 69.8% of participants were classified as

SUBMITTER: Hartley SL 

PROVIDER: S-EPMC10840615 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature