ATN cerebrospinal fluid biomarkers in dementia with Lewy bodies: Initial results from the United States Dementia with Lewy Bodies Consortium.

ABSTRACT:

Introduction

The National Institute on Aging - Alzheimer's Association (NIA-AA) ATN research framework proposes to use biomarkers for amyloid (A), tau (T), and neurodegeneration (N) to stage individuals with AD pathological features and track changes longitudinally. The overall aim was to utilize this framework to characterize pre-mortem ATN status longitudinally in a clinically diagnosed cohort of dementia with Lewy bodies (DLB) and to correlate it with the post mortem diagnosis.

Methods

The cohort was subtyped by cerebrospinal fluid (CSF) ATN category. A subcohort had longitudinal data, and a subgroup was neuropathologically evaluated.

Results

We observed a significant difference in Aβ_42/40 after 12 months in the A+T- group. Post mortem neuropathologic an

SUBMITTER: Jain L 

PROVIDER: S-EPMC10840643 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature