The association between gut microbiome and growth in infants with cystic fibrosis.

ABSTRACT:

Background

In cystic fibrosis (CF), pathophysiologic changes in the gastrointestinal tract lead to malnutrition and altered gut microbiome. Microbiome alterations have been linked to linear growth, gut inflammation and respiratory manifestations. Elucidating these gut microbiome alterations may provide insight into future nutritional management in CF.

Methods

Infants were followed for 12-months at four sites in the United States (US-CF) and Australia (AUS-CF). 16S rRNA gene sequencing was performed on longitudinal stool samples. Associations between microbial abundance and age, antibiotic prophylaxis, malnutrition, and breast feeding were evaluated using generalized linear mixed models. Taxonomic and predictive functional features were compared between groups.

Results

SUBMITTER: Deschamp AR 

PROVIDER: S-EPMC10840679 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature