Gene-respiratory disease interactions for rheumatoid arthritis risk.

ABSTRACT:

Objective

We aimed to identify gene by respiratory tract disease interactions that increase RA risk.

Methods

In this case-control study using the Mass General Brigham Biobank, we matched incident RA cases, confirmed by ACR/EULAR criteria, to four controls on age, sex, and electronic health record history. Genetic exposures included a validated overall genetic risk score (GRS) for RA, a Human Leukocyte Antigen (HLA) GRS for RA, and the MUC5B promoter variant, an established risk factor for RA-associated interstitial lung disease (ILD). Preceding respiratory tract diseases came from diagnosis codes (positive predictive value 86%). We estimated attributable proportions (AP) and multiplicative odds ratios (OR) with 95% confidence intervals (CI) for RA for each genetic and respir

SUBMITTER: Kronzer VL 

PROVIDER: S-EPMC10840753 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature