Autonomous animal heating and cooling system for temperature-regulated magnetic resonance experiments.

ABSTRACT: Temperature is a hallmark parameter influencing almost all magnetic resonance properties (e.g., T₁ , T₂ , proton density, and diffusion). In the preclinical setting, temperature has a large influence on animal physiology (e.g., respiration rate, heart rate, metabolism, and oxidative stress) and needs to be carefully regulated, especially when the animal is under anesthesia and thermoregulation is disrupted. We present an open-source heating and cooling system capable of regulating the temperature of the animal. The system was designed using Peltier modules capable of heating or cooling a circulating water bath with active temperature feedback. Feedback was obtained using a commercial thermistor, placed in the animal rectum, and a proportional-integral-derivative contr

SUBMITTER: Verghese G 

PROVIDER: S-EPMC10840815 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature