Delirium is associated with loss of feedback cortical connectivity.

ABSTRACT:

Introduction

Post-operative delirium (POD) is associated with increased morbidity and mortality but is bereft of treatments, largely due to our limited understanding of the underlying pathophysiology. We hypothesized that delirium reflects a disturbance in cortical connectivity that leads to altered predictions of the sensory environment.

Methods

High-density electroencephalogram recordings during an oddball auditory roving paradigm were collected from 131 patients. Dynamic causal modeling (DCM) analysis facilitated inference about the neuronal connectivity and inhibition-excitation dynamics underlying auditory-evoked responses.

Results

Mismatch negativity amplitudes were smaller in patients with POD. DCM showed that delirium was associated with decreased left-sided s

SUBMITTER: Gjini K 

PROVIDER: S-EPMC10840828 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature