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Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites.

ABSTRACT: Studies on the control of eukaryotic translation initiation by a cap-independent recruitment of the 40S ribosomal subunit to internal messenger RNA sequences called internal ribosome entry sites (IRESs) have shown that these sequence elements are present in a growing list of viral and cellular RNAs. Here we discuss their prevalence, mechanisms whereby they may function and their uses in regulating gene expression.

SUBMITTER: Vagner S

PROVIDER: S-EPMC1084086 | biostudies-literature | 2001 Oct

REPOSITORIES: biostudies-literature

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Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites.

Vagner S S Galy B B Pyronnet S S

EMBO reports 20011001 10

Studies on the control of eukaryotic translation initiation by a cap-independent recruitment of the 40S ribosomal subunit to internal messenger RNA sequences called internal ribosome entry sites (IRESs) have shown that these sequence elements are present in a growing list of viral and cellular RNAs. Here we discuss their prevalence, mechanisms whereby they may function and their uses in regulating gene expression. ...[more]

PMID: 11600453

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