Blunted Neurobehavioral Loss Anticipation Predicts Relapse to Stimulant Drug Use.

ABSTRACT:

Background

Patients with stimulant use disorder experience high rates of relapse. While neurobehavioral mechanisms involved in initiating drug use have been studied extensively, less research has focused on relapse.

Methods

To assess motivational processes involved in relapse and diagnosis, we acquired functional magnetic resonance imaging responses to nondrug (monetary) gains and losses in detoxified patients with stimulant use disorder (n = 68) and community control participants (n = 42). In a prospective multimodal design, we combined imaging of brain function, brain structure, and behavior to longitudinally track subsequent risk for relapse.

Results

At the 6-month follow-up assessment, 27 patients remained abstinent, but 33 had relapsed. Patients with blunted ante

SUBMITTER: Mortazavi L 

PROVIDER: S-EPMC10840879 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature