Anaplastic large cell lymphomas with equivocal DUSP22 FISH results: recommendations for clinical reporting and diagnostic evaluation.

ABSTRACT: Anaplastic large cell lymphoma (ALCL), one of the most common T-cell lymphomas, shows unifying pathological features but is clinically and genetically heterogeneous. One genetic subgroup, characterized by recurrent DUSP22 rearrangements (R), has distinct morphologic, immunophenotypic, and molecular features and can be identified in routine pathology practice using a breakapart (BAP) fluorescence in situ hybridization (FISH) probe. However, some cases show equivocal BAP-FISH findings (BAP-FISH^EQ) and the features of these cases are poorly understood. Here, we sought to characterize DUSP22 BAP-FISH^EQ ALCLs further. First, we applied an immunohistochemistry (IHC) algorithm using TIA1, pSTAT3^Y705, and LEF1, which can predict DUSP22-R with high accuracy. Among 3

SUBMITTER: Fadl A 

PROVIDER: S-EPMC10840904 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature