Metabolic Dysfunction, Triglyceride-Glucose Index, and Risk of Severe Asthma Exacerbation.

ABSTRACT:

Background

Metabolic conditions may worsen asthma. There is a need to define a composite biomarker of metabolic dysfunction that has relevance to asthma outcomes.

Objective

To determine the association of the triglyceride-glucose index (TyG), a biomarker of metabolic syndrome and insulin resistance, with risk of severe asthma exacerbation.

Methods

A 5-year retrospective cohort of patients with asthma receiving health care from the US Veterans Health Administration from January 1, 2015, to December 31, 2019, was constructed. Fasting TyG values were extracted. Patients were followed for a severe asthma exacerbation, defined as an asthma-related corticosteroid prescription fill or an emergency encounter or hospitalization for asthma. Adjusted models estimated the relativ

SUBMITTER: Staggers KA 

PROVIDER: S-EPMC10840907 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature