Citrobacter rodentium possesses a functional type II secretion system necessary for successful host infection.

ABSTRACT: Infectious diarrheal diseases are the third leading cause of mortality in young children, many of which are driven by Gram-negative bacterial pathogens. To establish successful host infections these pathogens employ a plethora of virulence factors necessary to compete with the resident microbiota, and evade and subvert the host defenses. The type II secretion system (T2SS) is one such conserved molecular machine that allows for the delivery of effector proteins into the extracellular milieu. To explore the role of the T2SS during natural host infection, we used Citrobacter rodentium, a murine enteric pathogen, as a model of human intestinal disease caused by pathogenic Escherichia coli such as Enteropathogenic and Enterohemorrhagic E. coli (EPEC and EHEC). In this stud

SUBMITTER: Krekhno Z 

PROVIDER: S-EPMC10841016 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature