Exploring substrate-microbe interactions: a metabiotic approach toward developing targeted synbiotic compositions.

ABSTRACT: Gut microbiota is an important modulator of human health and contributes to high inter-individual variation in response to food and pharmaceutical ingredients. The clinical outcomes of interventions with prebiotics, probiotics, and synbiotics have been mixed and often unpredictable, arguing for novel approaches for developing microbiome-targeted therapeutics. Here, we review how the gut microbiota determines the fate of and individual responses to dietary and xenobiotic compounds via its immense metabolic potential. We highlight that microbial metabolites play a crucial role as targetable mediators in the microbiota-host health relationship. With this in mind, we expand the concept of synbiotics beyond prebiotics' role in facilitating growth and engraftment of probiotics, by focusing on mi

SUBMITTER: Speckmann B 

PROVIDER: S-EPMC10841028 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature