Molecular pathways underlying lung-brain axis signaling in asthma: Relevance for psychopathology and neuroinflammation.

ABSTRACT:

Background

Accumulating evidence indicates that asthma has systemic effects and affects brain function. Although airway inflammation is proposed to initiate afferent communications with the brain, the signaling pathways have not been established.

Objective

We sought to identify the cellular and molecular pathways involved in afferent lung-brain communication during airway inflammation in asthma.

Methods

In 23 adults with mild asthma, segmental bronchial provocation with allergen (SBP-Ag) was used to provoke airway inflammation and retrieve bronchoalveolar lavage fluid for targeted protein analysis and RNA sequencing to determine gene expression profiles. Neural responses to emotional cues in nodes of the salience network were assessed with functional magnetic resonanc

SUBMITTER: Dill-McFarland KA 

PROVIDER: S-EPMC10841090 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature