Retrieval and savings of contextual fear memories across an extended retention interval in juvenile and adult male and female rats.

ABSTRACT: Adult rodents exhibit an exceptional ability to retrieve context fear memories across lengthy retention intervals. In contrast, these memories established in younger rodents are susceptible to significant forgetting. The present study aimed to examine the persistence of contextual fear memories established in juvenile and adult Long-Evans male and female rats. Testing 1-day after conditioning, adult males exhibited evidence for greater conditioning than juvenile males, while in females, conditioning did not differ between juvenile and adult rats. In adults, males displayed greater conditioning than females, while in juveniles, males and females reached similar conditioning levels. At the 60-day retention interval, adult sex differences were maintained; however, juvenile rats failed to retr

SUBMITTER: Odynocki N 

PROVIDER: S-EPMC10841099 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature