Contributions of carotid bodies, retrotrapezoid nucleus neurons and preBotzinger complex astrocytes to the CO₂ -sensitive drive for breathing.

ABSTRACT: Current models of respiratory CO₂ chemosensitivity are centred around the function of a specific population of neurons residing in the medullary retrotrapezoid nucleus (RTN). However, there is significant evidence suggesting that chemosensitive neurons exist in other brainstem areas, including the rhythm-generating region of the medulla oblongata - the preBötzinger complex (preBötC). There is also evidence that astrocytes, non-neuronal brain cells, contribute to central CO₂ chemosensitivity. In this study, we reevaluated the relative contributions of the RTN neurons, the preBötC astrocytes, and the carotid body chemoreceptors in mediating the respiratory responses to CO₂ in experimental animals (adult laboratory rats). To block astroglial signalling via exo

SUBMITTER: SheikhBahaei S 

PROVIDER: S-EPMC10841148 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature