Polygenic risk scores identify heterogeneity in asthma and chronic obstructive pulmonary disease.

ABSTRACT:

Background

Asthma and chronic obstructive pulmonary disease (COPD) have distinct and overlapping genetic and clinical features.

Objective

We sought to test the hypothesis that polygenic risk scores (PRSs) for asthma (PRS_Asthma) and spirometry (FEV₁ and FEV₁/forced vital capacity; PRS_spiro) would demonstrate differential associations with asthma, COPD, and asthma-COPD overlap (ACO).

Methods

We developed and tested 2 asthma PRSs and applied the higher performing PRS_Asthma and a previously published PRS_spiro to research (Genetic Epidemiology of COPD study and Childhood Asthma Management Program, with spirometry) and electronic health record-based (Mass General Brigham Biobank and Genetic Epidemiology Resea

SUBMITTER: Moll M 

PROVIDER: S-EPMC10841234 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature