Investigation of sex differences in mutation carriers of the Dominantly Inherited Alzheimer Network.

ABSTRACT:

Introduction

Studies suggest distinct differences in the development, presentation, progression, and response to treatment of Alzheimer's disease (AD) between females and males. We investigated sex differences in cognition, neuroimaging, and fluid biomarkers in dominantly inherited AD (DIAD).

Methods

Three hundred twenty-five mutation carriers (55% female) and one hundred eighty-six non-carriers (58% female) of the Dominantly Inherited Alzheimer Network Observational Study were analyzed. Linear mixed models and Spearman's correlation explored cross-sectional sex differences in cognition, cerebrospinal fluid (CSF) biomarkers, Pittsburgh compound B positron emission tomography (¹¹ C-PiB PET) and structural magnetic resonance imaging (MRI).

Results

Female carr

SUBMITTER: Wagemann O 

PROVIDER: S-EPMC10841236 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature