Cannabis use may attenuate neurocognitive performance deficits resulting from methamphetamine use disorder.

ABSTRACT:

Objective

Methamphetamine and cannabis are two widely used, and frequently co-used, substances with possibly opposing effects on the central nervous system. Evidence of neurocognitive deficits related to use is robust for methamphetamine and mixed for cannabis. Findings regarding their combined use are inconclusive. We aimed to compare neurocognitive performance in people with lifetime cannabis or methamphetamine use disorder diagnoses, or both, relative to people without substance use disorders.

Method

423 (71.9% male, aged 44.6 ± 14.2 years) participants, stratified by presence or absence of lifetime methamphetamine (M-/M+) and/or cannabis (C-/C+) DSM-IV abuse/dependence, completed a comprehensive neuropsychological, substance use, and psychiatric assessment. Neurocognitiv

SUBMITTER: Rogers JM 

PROVIDER: S-EPMC10841263 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature