Localised non-metastatic sarcomatoid renal cell carcinoma: a 31-year externally verified study.

ABSTRACT:

Objective

To evaluate post-nephrectomy outcomes and predictors of cancer-specific survival (CSS) between patients with localised sarcomatoid renal cell carcinoma (sRCC) and those with Grade 4 RCC (non-sRCC), as most sRCC research focuses on advanced or metastatic disease with limited studies analysing outcomes of patients with localised non-metastatic sRCC.

Patients and methods

A total of 564 patients with localised RCC underwent partial or radical nephrectomy between June 1988 to March 2019 for sRCC (n = 204) or World Health Organization/International Society of Urological Pathology Grade 4 non-sRCC (n = 360). The CSS at every stage between groups was assessed. Phase III ASSURE clinical trial data were used to externally validate the CSS findings. The Mann-Whitney U-test an

SUBMITTER: Blum KA 

PROVIDER: S-EPMC10841268 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature