PACSIN2 regulates platelet integrin β1 hemostatic function.

ABSTRACT:

Background

Upon vessel injury, platelets adhere to exposed matrix constituents via specific membrane receptors, including the von Willebrand factor receptor glycoprotein (GP)Ib-IX-V complex and integrins β1 and β3. In platelets, the Fes/CIP4-homology Bin-Amphiphysin-Rvs protein PACSIN2 associates with the cytoskeletal and scaffolding protein filamin A (FlnA), linking GPIbα and integrins to the cytoskeleton.

Objectives

Here we investigated the role of PACSIN2 in platelet function.

Methods

Platelet parameters were evaluated in mice lacking PACSIN2 and platelet integrin β1.

Results

Pacsin2^-/- mice displayed mild thrombocytopenia, prolonged bleeding time, and delayed thrombus formation in a ferric chloride-mediated carotid artery injury model, which was

SUBMITTER: Biswas R 

PROVIDER: S-EPMC10841284 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature