A fetal wound healing program after intrauterine bile duct injury may contribute to biliary atresia.

ABSTRACT:

Background & aims

Biliary atresia (BA) is an obstructive cholangiopathy that initially affects the extrahepatic bile ducts (EHBDs) of neonates. The etiology is uncertain, but evidence points to a prenatal cause. Fetal tissues have increased levels of hyaluronic acid (HA), which plays an integral role in fetal wound healing. The objective of this study was to determine whether a program of fetal wound healing is part of the response to fetal EHBD injury.

Methods

Mouse, rat, sheep, and human EHBD samples were studied at different developmental time points. Models included a fetal sheep model of prenatal hypoxia, human BA EHBD remnants and liver samples taken at the time of the Kasai procedure, EHBDs isolated from neonatal rats and mice, and spheroids and other models generated

SUBMITTER: de Jong IEM 

PROVIDER: S-EPMC10841314 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature