Extracellular SOD modulates canonical TNFα signaling and α5β1 integrin transactivation in vascular smooth muscle cells.

ABSTRACT: TNFα activates NADPH oxidase 1 (Nox1) in vascular smooth muscle cells (VSMCs). The extracellular superoxide anion (O₂^•-) produced is essential for the pro-inflammatory effects of the cytokine but the specific contributions of O₂^•- to signal transduction remain obscure. Extracellular superoxide dismutase (ecSOD, SOD3 gene) is a secreted protein that binds to cell surface heparin sulfate proteoglycans or to Fibulin-5 (Fib-5, FBLN5 gene), an extracellular matrix protein that also associates with elastin and integrins. ecSOD converts O₂^•- to hydrogen peroxide (H₂O₂) which prevents NO^• inactivation, limits generation of hydroxyl radical (OH^•), and creates high local concentrations of H<

SUBMITTER: Choi H 

PROVIDER: S-EPMC10841345 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature