Novel insights into the whole-blood DNA methylome of asthma in ethnically diverse children and youth.

ABSTRACT:

Background

The epigenetic mechanisms of asthma remain largely understudied in African Americans and Hispanics/Latinos, two populations disproportionately affected by asthma. We aimed to identify markers, regions and processes with differential patterns of DNA methylation (DNAm) in whole blood by asthma status in ethnically diverse children and youth, and to assess their functional consequences.

Methods

DNAm levels were profiled with the Infinium MethylationEPIC or HumanMethylation450 BeadChip arrays among 1226 African Americans or Hispanics/Latinos and assessed for differential methylation per asthma status at the CpG and region (differentially methylated region (DMR)) level. Novel associations were validated in blood and/or nasal epithelium from ethnically diverse children

SUBMITTER: Herrera-Luis E 

PROVIDER: S-EPMC10841414 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature