Maternal steroids during pregnancy and their associations with exposure to lifetime stressful life events, prenatal stress appraisal and psychological functioning.

ABSTRACT:

Background

During pregnancy, steroids enable physiological adaptations in response to many factors, including maternal stress or psychological functioning. While stress and psychological dysfunction can have endocrine-disrupting effects beyond cortisol disruption, associations between prenatal maternal stress or related psychological dysfunction and the broader steroid milieu remain understudied.

Aim

To assess associations between independent and joint maternal stress and psychological functioning measures and steroid profiles in pregnancy (22-40 gestational weeks) in the Programming of Intergenerational Stress Mechanisms (PRISM) birth cohort (n = 334).

Methods

Serum metabolomics detected 42 steroids and their metabolites, which were grouped into five classes (pregnen

SUBMITTER: Colicino E 

PROVIDER: S-EPMC10841416 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature