Improving Early Recognition of Treatment-Responsive Causes of Rapidly Progressive Dementia: The STAM₃ P Score.

ABSTRACT:

Objective

To improve the timely recognition of patients with treatment-responsive causes of rapidly progressive dementia (RPD).

Methods

A total of 226 adult patients with suspected RPD were enrolled in a prospective observational study and followed for up to 2 years. Diseases associated with RPD were characterized as potentially treatment-responsive or non-responsive, referencing clinical literature. Disease progression was measured using Clinical Dementia Rating® Sum-of-Box scores. Clinical and paraclinical features associated with treatment responsiveness were assessed using multivariable logistic regression. Findings informed the development of a clinical criterion optimized to recognize patients with potentially treatment-responsive causes of RPD early in the diagnostic

SUBMITTER: Satyadev N 

PROVIDER: S-EPMC10841446 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature