Association between substantia nigra degeneration and functional outcome in patients with basal ganglia infarction.

ABSTRACT:

Background and purpose

Cerebral infarction in the basal ganglia may cause secondary and delayed neuronal degeneration in the substantia nigra (SN). However, the clinical significance of SN degeneration remains poorly understood.

Methods

This retrospective observational study included patients with acute ischemic stroke in the basal ganglia on initial diffusion-weighted imaging who underwent follow-up diffusion-weighted imaging between 4 and 30 days after symptom onset. SN degeneration was defined as a hyperintensity lesion in the SN observed on diffusion-weighted imaging. We compared functional outcomes at 3 months between patients with and without SN degeneration. A poor outcome was defined as a score of 3-6 (functional dependence or death) on the modified Rankin Scale.

SUBMITTER: Lee H 

PROVIDER: S-EPMC10841447 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature