Circulating neutrophil-related proteins associate with incident heart failure and cardiac dysfunction: The ARIC study.

ABSTRACT:

Aims

Neutrophil activity contributes to adverse cardiac remodelling in experimental acute cardiac injury and is modifiable with pharmacologic agents like colchicine.

Methods and results

Neutrophil activity-related plasma proteins known to be affected by colchicine treatment were measured at Visit 3 (1993-1995) and Visit 5 (2011-2013) of the ARIC cohort study. A protein-based neutrophil activity score was derived from 10 candidate proteins using LASSO Cox regression. Associations with incident heart failure (HF) and with cardiac function using Cox proportional hazards regression and linear regression models, respectively. The mean ages at Visits 3 and 5 were 60 ± 6 and 75 ± 5 years, respectively, and 54% and 57% were women, respectively. Each 1-standard deviation increase in

SUBMITTER: Buckley LF 

PROVIDER: S-EPMC10841462 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature