Association of aflatoxin with gallbladder cancer in a case-control study nested within a Chinese cohort.

ABSTRACT: We evaluated whether aflatoxin B₁ (AFB₁ ) exposure was associated with later risk of developing gallbladder cancer (GBC). We measured AFB₁ -lysine albumin adducts in baseline samples from the Shanghai Cohort Study of 18 244 men aged 45 to 64 years (recruited 1986-1989). We included 84 GBC cases with sufficient serum and 168 controls matched on age at sample collection, date of blood draw and residence. We calculated adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for detectable vs non-detectable AFB₁ -lysine albumin adducts and gallbladder cancer. AFB₁ -lysine albumin adducts were detected in 50.0% of GBC cases, and risk of GBC was twice as high in those with detectable vs undetectable levels (OR = 2.0, 95% CI = 1.0-3

SUBMITTER: Koshiol J 

PROVIDER: S-EPMC10841509 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature