Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring.

ABSTRACT: Tumor microbiota can produce active metabolites that affect cancer and immune cell signaling, metabolism, and proliferation. Here, we explore tumor and gut microbiome features that affect chemoradiation response in patients with cervical cancer using a combined approach of deep microbiome sequencing, targeted bacterial culture, and in vitro assays. We identify that an obligate L-lactate-producing lactic acid bacterium found in tumors, Lactobacillus iners, is associated with decreased survival in patients, induces chemotherapy and radiation resistance in cervical cancer cells, and leads to metabolic rewiring, or alterations in multiple metabolic pathways, in tumors. Genomically similar L-lactate-producing lactic acid bacteria commensal to other body sites are also significantly associated w

SUBMITTER: Colbert LE 

PROVIDER: S-EPMC10841640 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature