A 3D-printed phantom for quality-controlled reproducibility measurements of arterial spin labeled perfusion.

ABSTRACT:

Purpose

To develop a portable MR perfusion phantom for quality-controlled assessment and reproducibility of arterial spin labeled (ASL) perfusion measurement.

Methods

A 3D-printed perfusion phantom was developed that mimics the branching of arterial vessels, capillaries, and a chamber containing cellulose sponge representing tissue characteristics. A peristaltic pump circulated distilled water through the phantom, and was first evaluated at 300, 400, and 500 mL/min. Longitudinal reproducibility of perfusion was performed using 2D pseudo-continuous ASL at 20 post-label delays (PLDs, ranging between 0.2 and 7.8 s at 0.4-s intervals) over a period of 16 weeks, with three repetitions each week. Multi-PLD data were fitted into a general kinetic model for perfusion quantification

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10841664 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature