Levels of plasma brain-derived tau and p-tau181 in Alzheimer's disease and rapidly progressive dementias.

ABSTRACT:

Introduction

Rapidly progressive dementias (RPDs) are a group of neurological disorders characterized by a rapid cognitive decline. The diagnostic value of blood-based biomarkers for Alzheimer's disease (AD) in RPD has not been fully explored.

Methods

We measured plasma brain-derived tau (BD-tau) and p-tau181 in 11 controls, 15 AD patients, and 33 with RPD, of which 19 were Creutzfeldt-Jakob disease (CJD).

Results

Plasma BD-tau differentiated AD from RPD and controls (p = 0.002 and p = 0.03, respectively), while plasma and cerebrospinal fluid (CSF) p-tau181 distinguished AD from RPD (p < 0.001) but not controls from RPD (p > 0.05). The correlation of CSF t-tau with plasma BD-tau was stronger (r = 0.78, p < 0.001) than the correlation of CSF and plasma p-tau181 (r = 0.

SUBMITTER: Gonzalez-Ortiz F 

PROVIDER: S-EPMC10841678 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature