Long-acting injectable multipurpose prevention technology for prevention of HIV and unplanned pregnancy.

ABSTRACT: Only condoms are proven to protect against both HIV and unplanned pregnancy, however, poor user acceptability and lack of partner cooperation impede effectiveness. We developed an injectable ultra-long-acting, biodegradable, and removable in-situ forming implant (ISFI) as multipurpose prevention technology (MPT). MPT ISFIs co-formulated an antiretroviral (dolutegravir (DTG)) or cabotegravir (CAB)), and a hormonal contraceptive (etonogestrel (ENG) or medroxyprogesterone acetate (MPA)). All formulations were well-tolerated in mice with no signs of chronic local or systemic inflammation. Plasma CAB and DTG concentrations were above 4× PA-IC₉₀ for 90 days with zero-order and diffusion-controlled absorption, respectively, and no differences when co-formulated with either hormone. Pla

SUBMITTER: Young IC 

PROVIDER: S-EPMC10841820 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature