Adjustment of rotation and saturation effects (AROSE) for CEST imaging.

ABSTRACT:

Purpose

Endogenous CEST signal usually has low specificity due to contaminations from the magnetization transfer contrast (MTC) and other labile protons with overlapping or close Larmor frequencies. We propose to improve CEST signal specificity with adjustment of rotation and saturation effects (AROSE).

Methods

The AROSE approach measures the difference between CEST signals acquired with the same average irradiation power but largely different duty cycles, for example, a continuous wave or a high duty cycle pulse train versus a low duty cycle pulse train with a flip angle φ. Simulation, phantom, and in vivo rodent studies were performed to evaluate the characteristics of the AROSE_φ signal.

Results

Simulation and experimental results show that AROSE_2π</

SUBMITTER: Jin T 

PROVIDER: S-EPMC10841829 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature