Interplay between diet, circulating indolepropionate concentrations and cardiometabolic health in US populations.

ABSTRACT:

Objectives

To identify indolepropionate (IPA)-predicting gut microbiota species, investigate potential diet-microbiota interactions, and examine the prospective associations of circulating IPA concentrations with type 2 diabetes (T2D) and coronary heart disease (CHD) risk in free-living individuals.

Design

We included 287 men from the Men's Lifestyle Validation Study, a substudy of the Health Professionals Follow-Up Study (HPFS), who provided up to two pairs of faecal samples and two blood samples. Diet was assessed using 7-day diet records. Associations between plasma concentrations of tryptophan metabolites and T2D CHD risk were examined in 13 032 participants from Nurses' Health Study (NHS), NHSII and HPFS.

Results

We identified 17 microbial species whose abundance

SUBMITTER: Hu Y 

PROVIDER: S-EPMC10841831 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature