Impact of donor-recipient age-difference in adolescent heart transplantation.

ABSTRACT:

Introduction

The relationship between donor age and adolescent heart transplant outcomes remains incompletely understood. We aimed to explore the effect of donor-recipient age difference on survival after adolescent heart transplantation.

Methods

The United Network for Organ Sharing database was used to identify 2,855 adolescents aged 10-17 years undergoing isolated primary heart transplantation from 1/1/2000 to 12/31/2022. The primary outcome was 10-year post-transplant survival. Multivariable Cox regression identified predictors of mortality after adjusting for donor and recipient characteristics. A restricted cubic spline assessed the non-linear association between donor-recipient age-difference and the adjusted relative mortality hazard.

Results

The median donor-r

SUBMITTER: Gill G 

PROVIDER: S-EPMC10841908 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature