Modulating glucocorticoid receptor actions in physiology and pathology: Insights from coregulators.

ABSTRACT: Glucocorticoids (GCs) are a class of steroid hormones that regulate key physiological processes such as metabolism, immune function, and stress responses. The effects of GCs are mediated by the glucocorticoid receptor (GR), a ligand-dependent transcription factor that activates or represses the expression of hundreds to thousands of genes in a tissue- and physiological state-specific manner. The activity of GR is modulated by numerous coregulator proteins that interact with GR in response to different stimuli assembling into a multitude of DNA-protein complexes and facilitate the integration of these signals, helping GR to communicate with basal transcriptional machinery and chromatin. Here, we provide a brief overview of the physiological and molecular functions of GR, and discuss the rol

SUBMITTER: Fadel L 

PROVIDER: S-EPMC10841922 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature