A ribose-functionalized NAD⁺ with versatile activity for ADP-ribosylation.

ABSTRACT: An NAD⁺ featuring an adenosyl 4'-azido functions as a general substrate for poly-ADP-ribose polymerases. Its derived mono- and poly-ADP-ribosylated proteins can be adequately recognized by distinct ADP-ribosylation-specific readers. This molecule represents the first ribose-functionalized NAD⁺ with versatile activities across different ADP-ribosyltransferases and provides insight into developing new probes for ADP-ribosylation.

SUBMITTER: Stephens EN 

PROVIDER: S-EPMC10841986 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature