The association between inflammatory bowel disease and all-cause and cause-specific mortality in the UK Biobank.

ABSTRACT:

Purpose

Inflammatory bowel disease (IBD) has a rising global prevalence. However, the understanding of its impact on mortality remains inconsistent so we explored the association between IBD and all-cause and cause-specific mortality.

Methods

This study included 502,369 participants from the UK Biobank, a large, population-based, prospective cohort study with mortality data through 2022. IBD was defined by baseline self-report or from primary care or hospital admission data. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortality in multivariable Cox proportional hazards regression models.

Results

A total of 5799 (1.2%) participants had a history of IBD at baseline. After a median follow-up of 13.7 years, 44,499 d

SUBMITTER: Li F 

PROVIDER: S-EPMC10842122 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature