A manifold neural population code for space in hippocampal coactivity dynamics independent of place fields.

ABSTRACT: Hippocampus place cell discharge is temporally unreliable across seconds and days, and place fields are multimodal, suggesting an "ensemble cofiring" spatial coding hypothesis with manifold dynamics that does not require reliable spatial tuning, in contrast to hypotheses based on place field (spatial tuning) stability. We imaged mouse CA1 (cornu ammonis 1) ensembles in two environments across three weeks to evaluate these coding hypotheses. While place fields "remap," being more distinct between than within environments, coactivity relationships generally change less. Decoding location and environment from 1-s ensemble location-specific activity is effective and improves with experience. Decoding environment from cell-pair coactivity relationships is also effective and improves with experi

SUBMITTER: Levy ERJ 

PROVIDER: S-EPMC10842170 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature