Filifactor alocis enhances survival of Porphyromonas gingivalis W83 in response to H₂ O₂ -induced stress.

ABSTRACT: A dysbiotic microbial community whose members have specific/synergistic functions that are modulated by environmental conditions, can disturb homeostasis in the subgingival space leading to destructive inflammation, plays a role in the progression of periodontitis. Filifactor alocis, a gram-positive, anaerobic bacterium, is a newly recognized microbe that shows a strong correlation with periodontal disease. Our previous observations suggested F. alocis to be more resistant to oxidative stress compared to Porphyromonas gingivalis. The objective of this study is to further determine if F. alocis, because of its increased resistance to oxidative stress, can affect the survival of other 'established' periodontal pathogens under environmental stress conditions typical of the periodontal pocket.

SUBMITTER: Mishra A 

PROVIDER: S-EPMC10842171 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature