Voluntary wheel running prevents formation of membrane attack complexes and myelin degradation after peripheral nerve injury.

ABSTRACT: Regular aerobic activity is associated with a reduced risk of chronic pain in humans and rodents. Our previous studies in rodents have shown that prior voluntary wheel running can normalize redox signaling at the site of peripheral nerve injury, attenuating subsequent neuropathic pain. However, the full extent of neuroprotection offered by voluntary wheel running after peripheral nerve injury is unknown. Here, we show that six weeks of voluntary wheel running prior to chronic constriction injury (CCI) reduced the terminal complement membrane attack complex (MAC) at the sciatic nerve injury site. This was associated with increased expression of the MAC inhibitor CD59. The levels of upstream complement components (C3) and their inhibitors (CD55, CR1 and CFH) were altered by CCI, but not incr

SUBMITTER: Green-Fulgham SM 

PROVIDER: S-EPMC10842182 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature