Identification of Clinical Drivers of Left Atrial Enlargement Through Genomics of Left Atrial Size.

ABSTRACT:

Background

Greater left atrial size is associated with a higher incidence of cardiovascular disease and mortality, but the full spectrum of diagnoses associated with left atrial enlargement in sex-stratified clinical populations is not well known. Our study sought to identify genetic risk mechanisms affecting left atrial diameter (LAD) in a clinical cohort.

Methods

Using Vanderbilt deidentified electronic health record, we studied 6163 females and 5993 males of European ancestry who had at least 1 LAD measure and available genotyping. A sex-stratified polygenic score was constructed for LAD variation and tested for association against 1680 International Classification of Diseases code-based phenotypes. Two-sample univariable and multivariable Mendelian randomization a

SUBMITTER: Agrawal V 

PROVIDER: S-EPMC10842187 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature