Maternal prenatal social experiences and offspring epigenetic age acceleration from birth to mid-childhood.

ABSTRACT:

Purpose

Investigate associations of maternal social experiences with offspring epigenetic age acceleration (EAA) from birth through mid-childhood among 205 mother-offspring dyads of minoritized racial and ethnic groups.

Methods

We used linear regression to examine associations of maternal experiences of racial bias or discrimination (0 = none, 1-2 = intermediate, or 3+ = high), social support (tertile 1 = low, 2 = intermediate, 3 = high), and socioeconomic status index (tertile 1 = low, 2 = intermediate, 3 = high) during the prenatal period with offspring EAA according to Horvath's Pan-Tissue, Horvath's Skin and Blood, and Intrinsic EAA clocks at birth, 3 years, and 7 years.

Results

In comparison to children of women who did not experience any racial bias or discrimin

SUBMITTER: Laubach ZM 

PROVIDER: S-EPMC10842218 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature