Modeling Ventilator-Induced Lung Injury and Neutrophil Infiltration to Infer Injury Interdependence.

ABSTRACT: Acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI) are heterogeneous conditions. The spatiotemporal evolution of these heterogeneities is complex, and it is difficult to elucidate the mechanisms driving its progression. Through previous quantitative analyses, we explored the distributions of cellular injury and neutrophil infiltration in experimental VILI and discovered that VILI progression is characterized by both the formation of new injury in quasi-random locations and the expansion of existing injury clusters. Distributions of neutrophil infiltration do not correlate with cell injury progression and suggest a systemic response. To further examine the dynamics of VILI, we have developed a novel computational model that simulates damage (cellular injury

SUBMITTER: Mattson CL 

PROVIDER: S-EPMC10842244 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature