Fungal diversity in homes and asthma morbidity among school-age children in New York City.

ABSTRACT:

Background

Asthma development has been inversely associated with exposure to fungal diversity. However, the influence of fungi on measures of asthma morbidity is not well understood.

Objectives

This study aimed to test the hypothesis that fungal diversity is inversely associated with neighborhood asthma prevalence and identify specific fungal species associated with asthma morbidity.

Methods

Children aged 7-8 years (n = 347) living in higher (11-18%) and lower (3-9%) asthma prevalence neighborhoods were recruited within an asthma case-control study. Fungal communities were analyzed from floor dust using high-throughput DNA sequencing. A subset of asthmatic children (n = 140) was followed to age 10-11 to determine asthma persistence.

Results

Neighborhood asthma

SUBMITTER: Cochran SJ 

PROVIDER: S-EPMC10842248 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature