Real-world assessment of treatment inertia in the management of patients treated for major depressive disorder in the USA.

ABSTRACT: Aim: Major depressive disorder (MDD) is a debilitating illness in which depressive symptoms may persist after treatment. Treatment inertia is the continued use of the same pharmacotherapy regimen when treatment goals are not met. This study assessed the frequency of treatment inertia among adult patients with MDD treated in a real-world setting. Patients & methods: This was a retrospective, observational study of patients with MDD identified in the Decision Resources Group Real World Evidence US Data Repository from January 2014 to June 2018. Patients (≥18 years) had an elevated Patient Health Questionnaire-9 (PHQ-9) score (≥5) following 8 weeks of stable baseline antidepressant use with/without mental-health outpatient therapy. Treatment inertia, modification and discontinua

SUBMITTER: Sheehan JJ 

PROVIDER: S-EPMC10842298 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature