Longitudinal associations between early-life fluoride exposures and cardiometabolic outcomes in school-aged children.

ABSTRACT:

Background/aim

Fluoride is a natural mineral present in food, water, and dental products, constituting ubiquitous long-term exposure in early childhood and across the lifespan. Experimental evidence shows fluoride-induced lipid disturbances with potential implications for cardiometabolic health. However, epidemiological studies are scarce. For the first time, we evaluated associations between repeated fluoride measures and cardiometabolic outcomes in children.

Methods

We studied ∼ 500 Mexican children from the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) cohort with measurements on urinary fluoride at age 4, and dietary fluoride at ages 4, 6, and 8 years approximately. We used covariate-adjusted linear mixed-effects and linear regressi

SUBMITTER: India Aldana S 

PROVIDER: S-EPMC10842303 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature